関連施設等
谷垣専門研究員が日本分子生物学会で発表を行いました。
- 日付2025-12
- 発表日2025.12.4
- 学会名第48回日本分子生物学会
- 開催地横浜
- 演題Pituitary structure abnormalities of Notch4 knockout mice.
- 演者Kenji Tanigaki
- 要旨Notch4 has been reported to be associated with schizophrenia. Neuron-specific deletion of RBP-J enhanced dopamine responsiveness and reduced dopamine release in the striatum. RBP-J-mediated regulation of dopamine responsiveness might suggest the possible
- involvement of Notch/RBP-J signaling in schizophrenia. RBP-J-mediated regulation of dopamine responsiveness might suggest the possible involvement of Notch/RBP-J signaling in schizophrenia.
- However, it remains to be elucidated how Notch4 increases the risk of schizophrenia. Schizophrenia is characterized by cortisol level alteration, and affects stress reactivity.
- To elucidate the effects of Notch4 deficiency on Hypothalamus-Pituitary-Adrenal axis, we examined the pituitary structure of Notch4-deficient mice. We would like to discuss the possible roles of Notch4 in the pathogenesis of schizophrenia.
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