関連施設等
谷垣専門研究員が第45回日本分子生物学会で発表しました
- 日付2022年12月31日
- 発表日2022年11月30日
- 学会名第45回日本分子生物学会
- 開催地幕張メッセ
- 演題Neuropathological analysis of Notch4 knockout mice.
- 演者Kenji Tanigaki
- 要旨Notch4 has been reported to be associated with schizophrenia. Rats with reduced g-secretase activity show behavioral abnormalities such as increased sensitivity to apomorphine.
- Conditional deletion of RBP-J specifically in neuronal cells drastically reduced dopamine release in the striatum and caused a subtle decrease in the number of dopaminergic neurons.
- RBP-J signaling regulates dopamine responsiveness in the striatum, which night suggest the possible involvement of Notch/RBP-J signaling in schizophrenia. However, it remains to be elucidated how Notch4 interacts with RBP-J and increases the risk of schizophrenia.
- To elucidate the functions of Notch4 in the pathogenesis of schizophrenia, we performed behavioral analysis of Notch4-deficient mice and examined their responses to dopaminergic stimulation. We would like to discuss the possible roles of Notch4 in the pathogenesis of schizophrenia.
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