雑誌名Stroke 2022 Dec;53(12):e500-e503. doi: 10.1161/STROKEAHA.122.040493. Epub
2022 Nov 7.
著者Yamauchi H, Kagawa S, Kusano K, Ito M, Okuyama C
題名Misery Perfusion and Tau Deposition in Atherosclerotic Major Cerebral
Artery Disease: A 18F-Florzolotau Positron Emission Tomography Study
要旨Abstract:Background: Studies using animal models have shown that cerebral hypoperfusion causes hyperphosphorylation of tau protein, leading to
neuronal damage. However, the relationship between hypoperfusion and tau deposition in humans is unclear. Hence, we aimed to determine whether
cerebral hypoperfusion leading to decreased blood flow relative to metabolic demand [increased oxygen extraction fraction (OEF), misery
perfusion] is associated with increased tau deposition in patients with atherosclerotic internal carotid artery or middle cerebral artery disease.
Methods:We prospectively evaluated the distribution of tau aggregate deposition using positron emission tomography and 18F-florzolotau (PMPBB3
[1-fluoro-3-((2-((1E,3E)-4-(6-(methylamino)pyridine-3-yl)buta-1,3-dien-1-yl)benzo[d]thiazol-6-yl)oxy)propan-2-ol)]) in 8 patients with
atherosclerotic disease of the internal carotid artery or middle cerebral artery.
The standardized uptake value ratio of 18F-florzolotau at 100 to 110 minutes after injection was calculated using the cerebellar cortex as a
reference region and was correlated with OEF obtained from 15O-gas positron emission tomography in the middle cerebral artery distributions.
Results: Significant decreases in cerebral blood flow and cerebral metabolic rate of oxygen and increases in OEF were found in the hemisphere
ipsilateral to the arterial lesion. 18F-florzolotau standardized uptake value ratio in this region was also greater than that in the contralateral
hemisphere. In the ipsilateral hemisphere, 18F-florzolotau standardized uptake value ratio positively correlated with OEF values.
Conclusions: This pilot study with a small sample size suggests that increases in OEF-misery perfusion-may be associated with increased tau
aggregates deposition in atherosclerotic internal carotid artery or middle cerebral artery disease.