関連施設等
奥山上席専門研究員が当研究所の人工アミノ酸製剤（MeAIB）を用いた形質細胞性腫瘍へのPETの評価について世界核医学会で発表しました。
- 日付2022-9-20
- 発表日2022-9-7～11
- 学会名The 13th World Federation of Nuclear Medicine and Biology (世界核医学会）
- 開催地京都国際会議場
- 演題C-11 MeAIB PET/CT in patients with plasma cell tumor
- 演者奥山上席専門研究員
- 要旨【Background/Aims】It is known that FDG-PET frequently fails to visualize plasma cell tumor (PCT). In this paper, we evaluated the utility ofC-11-α-methylamino isobutyric PET/CT. 【Methods】Nineteen patients with PCT,multiple myeloma (MM) -13、Mproteinemia without myeloma (MP) -6
- ,underwent both FDG and MeAIB PET/CT with at most 10 days interval between the two PET scans. Patient-based and lesion-based evaluation on the PET/CT findings using each tracer were performed. The intensity of diffuse marrow uptake,and the number and the SUV of focal accumulation were evaluated.
- In 4 cases with MM, the PET scans were repeated after chemotherapy and evaluated the utility compared to other laboratory data. This study was performed under an institutional review board-approved protocol, and written informed consents were obtained from all patients.
- 【Results】In cases with MM, MeAIB visualized more focal lesions than FDG in 8 of 13 cases including many sites without no apparent lytic changes on CT scan while FDG mainly visualized
- significant uptake on the lytic cites. Intense or moderate diffuse bone marrow accumulation was seen in 9 and 5 patients with MM on MeAIB and FDG, respectively, and in 4 and 2 cases with MP.
- MeAIB visualized residual lesions after chemotherapy as well while M protein or Bence-Jones protein had disappeared, that helped the physician to determine the treatment. On the other hand, abnormal uptakes were seen at fracture sites on healed old MM lesions.
- 【Conclusions】MeAIB-PET, an amino acid tracer transported through system A transporter, is superior to FDG-PET in visualizing MM lesions.
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