山内副所長らが執筆した論文がJournal of Stroke and Cerebrovascular disease 誌にonline掲載されました。

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山内副所長らが執筆した論文がJournal of Stroke and Cerebrovascular disease 誌にonline掲載されました。

経過観察時の受診間血圧変動が大きいと、脳循環代謝が悪化することを、PETを用いて、初めて明らかにしました。
掲載日2021年11月12日（Published online)
掲載雑誌名Journal of Stroke and Cerebrovascular disease
著者Hiroshi Yamauchi, Shinya Kagawa, Kuninori Kusano, Miki Ito, Chio Okuyama
表題Visit-to-visit blood pressure variations and hemodynamic deterioration in atherosclerotic major cerebral artery disease
要旨（目的）Visit-to-visit variations in blood pressure (BP) in patients with atherosclerotic major cerebral artery disease could impair the function of cerebral collaterals, leading to hemodynamic deterioration at follow-up.
However, few studies have investigated the relationship between visit-to-visit BP variability and changes in hemodynamic parameters at follow-up.
要旨（方法）We evaluated 35 medically treated patients with atherosclerotic internal carotid artery or middle cerebral artery disease with no ischaemic episodes during follow-up (mean: 35 ± 20 months)； these patients had a three-time visit for positron emission tomography examinations with 15O-gas.
Differences in the mean hemispheric values of hemodynamic parameters in the cortical territory of the diseased artery between the first and third examinations (changes at follow-up)
were correlated with the coefficient of variation (CoV) in three systolic BP (SBP) values at the examinations (BP variability during follow-up).
要旨（結果）CoV values were negatively correlated with changes in oxygen metabolism or cerebral blood flow/cerebral blood volume (CBF/CBV) ratio.
In 17 patients with higher CoV values (＞ group median, 0.072), decreases in CBF, cerebral metabolic rate of oxygen, and CBF/CBV ratio were observed at follow-up； CBV decreased in 18 patients without elevated CoV.
A higher CoV was associated with a lack of statin use.
要旨（結論）In patients with atherosclerotic major cerebral artery disease, high visit-to-visit SBP variations during follow-up may be associated with deterioration in cerebral hemodynamics and metabolism.
（＜https://authors.elsevier.com/sd/article/S105230572100611X＞ https://authors.elsevier.com/sd/article/S105230572100611X）

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山内副所長らが執筆した論文がJournal of Stroke and Cerebrovascular disease 誌にonline掲載されました。

山内副所長らが執筆した論文がJournal of Stroke and Cerebrovascular disease 誌にonline掲載されました。