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主な論文

PETイメージング部門

奥山 智緒(おくやま ちお)

  1. Okuyama C, Nakajima K, Yamasaki Y, Nishimura T. Prognostic value of myocardial perfusion imaging for cardiovascular events among asymptomatic Japanese patients with type 2 diabetes and mild renal dysfunction.  Nucl Med Commun. 34;328-332. 2013
  2. Sano Y, Okuyama C, Iehara T, Matsushima S, Yamada K, Hosoi H, Nishimura T.Semi-quantitative (123)I-MIBG estimation method compared with scoring system in follow-up of advanced neuroblastoma: utility of total MIBG retention ratio versus scoring method.  Ann Nucl Med 26 :462-470,2012.
  3. Fujiwara Y, Mizuno T, Okuyama C, Nagakane Y, Watanabe-Hosomi A, Kondo M, Kuriyama N, Tokuda T, Matsushima S, Nishimura T, Nakagawa M.Simultaneous impairment of intracranial and peripheral artery vasoreactivity in CADASIL patients. Cerebrovasc Dis33:128-134,2012.
  4. Kodani N, Okuyama C, Aibe N, Matsushima S, Yamazaki H. Utility of additional delayed post-therapeutic 131I whole-body scanning in patients with thyroid cancer. Clin Nucl Med.37:264-267,2012
  5. Nakajima K, Matsuo S, Okuyama C, Hatta T, Tsukamoto K, Nishimura S, Yamashina A, Kusuoka H, Nishimura T. Cardiac event risk in a Japanese population estimated by gated myocardial perfusion imaging, diabetes mellitus and chronic kidney disease. Circ J.76: 68-75,gated myocardial perfusion imaging, diabetes mellitus and chronic kidney disease. Circ J.76: 68-175, 2012
  6. Okuyama C, Nakajima K, Hatta T, Nishimura S, Kusuoka H, Yamashina A, Nishimura T. ncremental prognostic value of myocardial perfusion single photon emission computed tomography for patients with diabetes and chronic kidney disease. Nucl Med Commun:32 913-9193, 2012.
  7. Tazoe J, Okuyama C, Iehara T, Hosoi H, Nishimura T. Unusual fatty metamorphosis observed in diffuse liver metastases of stage 4S neuroblastoma. Pediatr Radiol.40:777-780, 2010
  8. Okuyama C, Kubota T, Matsushima S, Ushijima Y, Nishimura T. Intense FDG accumulation in idiopathic tumoral calcinosis. Clin Nucl Med 34: 230-232, 2009
  9. Ushijima Y, Okuyama C,Kubota T, Nakai T, Nishimura T. Resional cerebral blood flow in Alzheimer’s disease: comparison between short and long-term donepezil therapy. Ann Nucl Med 20(6): 425-429, 2006
  10. Yamagami T, Kanda K, Okuyama C, Nishimura T. Tc?99m-MIBI scintigraphy in evaluating the effect of hepatocyte growth factor gene therapy for peripheral arteriosclerosis obliterans. Ann Nucl Med 23: 205-208,2009
  11. Nishida K, Okuyama C, Kubota T,MatsushimaS,OdaM,AkazawaK,NishimuraT. Intramuralmetastasisofesophagealcarcinomatothereconstructed gastric tube detected by FDG PET/CT. Clin Nucl Med 34: 523-525, 2009
  12. Okuyama C, Kubota T, Matsushima S, Nishida K, Oda M, Takenaka H, Kishimoto S, Nishimura T. FDG avid patchy bone marrow misinterpreted as melanoma metastases to bone in a case of aplastic anemia. Clin Nucl Med 34: 927-930, 2009
  13. Kubota T, Ushijima Y, Okuyama C, Nishimura T. A region-of-interest template for three-dimensional stereotactic surface projection images: initial application to the analysis of Alzheimer’s disease and mild cognitive impairment. Nucl Med Commun. 27: 37-44,2006
  14. Nakai T, Okuyama C, Kubota T, Yamada K, Ushijima Y, Taniike K, Suzuki T, Nishimura T. Pitfalls of FDG-PET for the diagnosis of osteoblastic bone metastass in patients with breast cancer.Eur J Nucl Med Mol Imaging 32(11): 1253-1258, 2005
  15. Kobayashi K, Okuyama C, Kubota T, Nakai T, Ushijima Y, Nishimura T. Do short-time SPECT images of bone scintigraphy improve the diagnostic value in the evaluation of solitary lesions in the thoracic spine in patients with extraskeletal malignancies? Ann Nucl Med .19: 557-566, 2005
  16. Goto M, Okuyama C, Kubota T, Ushijima Y, Nishimura T. Assessment of the solid-state gamma camera to depict axillary sentinel lymph nodes in breast cancer patients. Ann Nucl Med 19(7): 627-631, 2005
  17. Kubota T, Ushijima Y, Yamada K, Okuyama C, Nakai T, Nishimura T. Diagnosis of Alzheimer’s disease using brain perfusion SPECT and MR imaging which modality achieves better diagnosis accuracy? Eur J Nucl Med Mol Imaging 32(4): 414-421, 2005
  18. Hirota T, Yamagami T, Nakamura T, Okuyama C, Ushijima Y, Nishimura T. Small pulmonary arteriovenous fistulae revealed by scintigraphy during selective injection of 99Tcm-macroaggregated albumin. Br J Radiol. 77: 445-448, 2004
  19. Nakai T, Okuyama C, Kubota T, Kobayashi K, Tsubokura T, Ushijima Y, Nishimura T. Pattern of 111In-chloride bone marrow scintigraphy in myelodysplastic syndrome; comparison with clinical characteristics. Ann Nucl Med 18(8): 675-680, 2004
  20. Okuyama C, Ushijima Y, Kubota T, Yoshida T, Nakai T, Kobayashi K, Nishimura T. 123I-Metaiodobenzylguanidine uptake In the nape of the neck of children: likely visualization of brown adipose tissue. J Nucl Med 44: 1421-1425, 2003
  21. Nakai T, Okuyama C, Kubota T, Kobayashi K, Ushijima Y, Nishimura T. Detection of parathyroid hyperplasia, lymph node metastasis from thyroid cancer, and thyroid adenomatous hyperplasia using Tc-99m MIBI. Clin Nucl Med 28 :984-985, 2003
  22. Okuyama C, Ushijima Y, Suzuki K, Kin Y, Tokuhiro M, Nakano Y, Nishimura T. Transient aphasia as late-onset seizure after embolization for dural arteriovenous malformation. Clin Nucl Med 28:685-686,2003
  23. Okuyama C, Sakane N, Yoshida T, Shima K, Kurosawa H, Kumamoto K, Ushijima Y, Nishimura T. 123I- or 125I-Meta- Iodobenzylguanidine visualization of Brown adipose tissue. J Nucl Med 43(9):1234-1240 ,2002
  24. Yuen S, Sawai K, Ushijima Y, Okuyama C, Yamagami T, Yamada K, Nishimura T. valuation of axillary status in breast cancer. CT-based determination of sentinel lymph node size. Acta Radiologica43 :579-586,2002
  25. Yamagami T, Nakamura T, Iida S, Kato T, Tanaka O, Matsushima S, Ito H, Okuyama C, Ushijima Y, Shiga K, Nishimura T. Hepatic encephalopathy secondary to intrahepatic portosystemic venous shunt: balloon-occuluded retrograde transvenous embolization with n-butyl cyanoacrylate and microcoils. Cardiovasc Intervent Radiol 25 :219-212,2002
  26. Ushijima Y,Okuyama C,Mori S,Nakamura T,Kubota T, Nishimura T. Relationship between cognitive function and regional cerebral blood flow In Alzheimer’s disease. Nucl Med Commun 23(8):779-784, 2002
  27. Yuen S, Sawai K, Ushijima Y, Okuyama C, Yamagami T, Yamada K, Nishimura T. Evaluation of axillary status In breast cancer. CT-based determination of sentinel lymph node size. Acta Radiologica 43:579-586, 2002
  28. Okamoto K, Ushijima Y, Okuyama C, Nakamura T, NishimuraT. Measurement of cerebral blood flow using graph plot analysis and I-123 Iodoamphetamine. Clin Nucl Med 27(3):191-196, 2002
  29. Okuyama C, Ushijima Y, Kubota T, Nakamura T, Kikkawa M, Nishimura T. Utility of follow-up studies using meta- [123I]-Iodobenzylguanidine scintigraphy for detecting recurrent neuroblastoma. Nucl Med Commun 23(7): 663-672, 2002
  30. Kikkawa M, Nakamura T, Sakamoto K, Sugihara H, Azuma A, Sawada T, Okuyama C, Ushijima Y, Nishimura T. Assessment of left ventricular diastolic function from quantitative electrocardiogfaphic-gated 99mTc-tetrofosmin myocardial SPET. Eur J Nucl Med 28(5) :593-601, 2001
  31. Kubota T, Ushijima Y, Okuyama C, Kubo T, NishimuraT. Tracer accumulation in femoral head during early phase of bone scintigraphy after renal transplantation. J Nucl Med 42(12): 1789-1794, 2001
  32. OkuyamaC, UshijimaY, Kikkawa M, Yamagami T, Nakamura T, Kobayashi K, Hirota T, Nishimura T.False-positive I-131 accumulation in a liver cyst in a patient with thyroid carcinoma. Clin Nucl Med 26 :198-201, 2001
  33. OkuyamaC, UshijimaY, Watanabe K, Nakamura T, Nishimura T. Diffuse Tl-201 accumulation in irradiated area. Clin Nucl Med 26 (4):369-371, 2001
  34. OkuyamaC, UshijimaY, Nakamura T, Nishimura T. Pseudo-neuroblastoma demonstrated by 123I-MIBG SPECT. Clin Nucl Med 26 (5): 474-475, 2001
  35. SugiharaH, Adachi Y, Nakamura T, Ohtsuki K, Okuyama C, Ushijima Y. Long-Term Follow-up of Myocardial Perfusion and Metabolic Images in a Patient With Hypertrophic Cardiomyopathy. Clin Nucl Med 25: 206-207 , 2000
  36. Sugihara H, Taniguchi Y, Kinoshita N, Nakamura T, Hirasaki S, Azuma A, Ushijima Y, Okuyama C, Nakagawa M, Maeda T. Reverse redistribution of Tc-99m-tetrofosmin in exercise myocardial SPECT in patients with hypertrophic cardiomyopathy. Ann Nucl Med 12:287-292,1998
  37. Okuyama C, Ushijima Y, Sugihara H, Okitsu S, Ito H, Maeda T. Increased Subglottic Gallium Uptake in Relapsing Polychondritis. J Nucl Med 39:1977-1979, 1998

加川 信也(かがわ しんや)

  1. Ono M, Cheng Y, Kimura H, Cui M, Kagawa S, Nishii R, Saji H. Novel (18)F-Labeled Benzofuran Derivatives with Improved Properties for Positron Emission Tomography (PET) Imaging of β-Amyloid Plaques in Alzheimer’s Brains. J Med Chem. 54(8): 2971-2979, 2011.
  2. Hirata M, Kanai Y, Naka S, Matsumuro K, Kagawa S, Yoshimoto M, Ohmomo Y. Evaluation of radioiodinated quinazoline derivative as a new ligand for EGF receptor tyrosine kinase activity using SPECT. Ann Nucl Med. 25(2): 117-124, 2011.
  3. Yamauchi H, Nishii R, Higashi T, Kagawa S, Fukuyama H. Silent cortical neuronal damage in atherosclerotic disease of the major cerebral arteries. J Cereb Blood Flow Metab. 31(3): 953-961, 2011.
  4. Yamauchi H, Nishii R, Higashi T, Kagawa S, Fukuyama H. Selective neuronal damage and Wisconsin Card Sorting Test performance in atherosclerotic occlusive disease of the major cerebral artery. J Neurol Neurosurg Psychiatry. 82(2): 150-156, 2011.
  5. Cheng Y, Ono M, Kimura H, Kagawa S, Nishii R, Kawashima H, Saji H. Fluorinated Benzofuran Derivatives for PET Imaging of β-Amyloid Plaques in Alzheimer’s Disease Brains. ACS Med. Chem. Lett. 1(7): 321-325, 2010.
  6. Cheng Y, Ono M, Kimura H, Kagawa S, Nishii R, Saji H. A novel 18F-labeled pyridyl benzofuran derivative for imaging of β-amyloid plaques in Alzheimer’s brains. Bioorg Med Chem Lett. 20(20): 6141-6144, 2010.
  7. Yamauchi H, Nishii R, Higashi T, Kagawa S, Fukuyama H. Hemodynamic compromise as a cause of internal border-zone infarction and cortical neuronal damage in atherosclerotic middle cerebral artery disease. Stroke. 40(12): 3730-3735, 2009.
  8. Kudo T, Hata T, Kagawa S, Kishibe Y, Iwasaki J, Okazawa H. Differences in early-phase tracer distribution in lung between 11C-acetate and 13N-ammonia. Nucl Med Commun. 30(5): 343-349, 2009.
  9. Kudo T, Hata T, Kagawa S, Kishibe Y, Iwasaki J, Nakano A, Okazawa H. Simple quantification of myocardial perfusion by pixel-by-pixel graphical analysis using carbon-11 acetate: comparison of the K-complexes of carbon-11 acetate and nitrogen-13 ammonia. Nucl Med Commun. 29(8): 679-685, 2008.
  10. Yamauchi H, Kudoh T, Kishibe Y, Iwasaki J, Kagawa S. Selective neuronal damage and chronic hemodynamic cerebral ischemia. Ann Neurol. 61(5): 454-465, 2007.
  11. Yamauchi H, Kudoh T, Kishibe Y, Iwasaki J, Kagawa S. Selective neuronal damage and borderzone infarction in carotid artery occlusive disease: a 11C-flumazenil PET study. J Nucl Med. 46(12): 1973-1979, 2005.
  12. Kagawa S, Nakano T, Inoue O, Nishimura T Effect of glutamatergic systems on in vivo binding of [(125)I] beta-CIT in the brain of a rat model of Parkinson’s disease. Synapse. 46(1): 38-44, 2002.
  13. 加川信也アミロイドイメージング:インビボアルツハイマー病診断を目指して. ファルマシア. 38(2): 161-162, 2002.
  14. M Hirata, S Kagawa, M Yoshimoto, and Y Ohmomo Synthesis and Characterization of Radioiodinated MD-230254: A New Ligand for Potential Imaging of Monoamine Oxidase B Activity by Single Photon Emission Computed Tomography. Chem. Pharm. Bull. 50(5): 609-614, 2002.
  15. 加川信也ポジトロン標識薬剤‐[18F]FDGの製造‐. 核医学技術. 23(1): 30-36, 2003.

ゲノム疫学研究部門

谷垣 健二(たにがき けんじ)

英文著書

  1. Sugita Y, Takada S, Tanigaki K, Muraki K, Uemura M, Hojo M, Miyamoto S. Inhibition of VEGF receptors induces pituitary apoplexy: An experimental study in mice.
    PLoS One. 2023 Mar 16;18(3):e0279634. doi: 10.1371/journal.pone.0279634. eCollection 2023. (equal correspondence)

  2. Miyamoto T, Murakami R, Hamanishi J, Tanigaki K, Hosoe Y, Mise N, Takamatsu S, Mise Y, Ukita M, Taki M, Yamanoi K, Horikawa N, Abiko K, Yamaguchi K, Baba T, Matsumura N, Mandai M.

    B7-H3 Suppresses Antitumor Immunity via the CCL2-CCR2-M2 Macrophage Axis and Contributes to Ovarian Cancer Progression.

    Cancer Immunol Res. 2022 Jan;10(1):56-69. doi: 10.1158/2326-6066.CIR-21-0407. Epub 2021 Nov 19.
  3. Hiramoto T, Sumiyoshi A, Yamauchi T, Tanigaki K, Shi Q, Kang G, Ryoke R, Nonaka H, Enomoto S, Izumi T, Bhat MA, Kawashima R, Hiroi N. Tbx1, a gene encoded in 22q11.2 copy number variant, is a link between alterations in fimbria myelination and cognitive speed in mice.

    Mol Psychiatry. 2022 Feb;27(2):929-938. doi: 10.1038/s41380-021-01318-4. Epub 2021 Nov 5. Machine learning of brain structural biomarkers for Alzheimer’s disease (AD) diagnosis, prediction of disease progression, and amyloid beta deposition in the Japanese population.
  4. Shiino A, Shirakashi Y, Ishida M, Tanigaki K; Japanese Alzheimer’s Disease Neuroimaging Initiative. Alzheimers Dement (Amst). 2021 Oct 14;13(1):e12246. doi: 10.1002/dad2.12246. eCollection 2021.

  5. Syaifullah AH, Shiino A, Kitahara H, Ito R, Ishida M, Tanigaki K. Machine Learning for Diagnosis of AD and Prediction of MCI Progression From Brain MRI Using Brain Anatomical Analysis Using Diffeomorphic Deformation. Front Neurol. 2021 Feb 5;11:576029. doi: 10.3389/fneur.2020.576029. eCollection 2020.

  6. Marttinen M, Ferreira CB, Paldanius KMA, Takalo M, Natunen T, Mäkinen P, Leppänen L, Leinonen V, Tanigaki K, Kang G, Hiroi N, Soininen H, Rilla K, Haapasalo A, Hiltunen M. PresynapticPresynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Aβ. Cells. 2020 Nov 15;9(11):2482. doi: 10.3390/cells9112482.

  7. Tanigaki K. Thalamocortical Circuit Dysfunctions in Schizophrenia: Insights From 22q11.2 Deletion Syndrome. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 Sep;5(9):842-843

  8. Kato R, Machida A, Nomoto K, Kang G, Hiramoto T, Tanigaki K, Mogi K, Hiroi N, Kikusui T. Maternal approach behaviors toward neonatal calls are impaired by mother’s experiences of raising pups with a risk gene variant for autism. Dev Psychobiol. 2020 Jun 23. doi: 10.1002/dev.22006

  9. Takada S, Hojo M, Takebe N, Tanigaki K, Miyamoto S. Role of Endothelial-to-Mesenchymal Transition in the Pathogenesis of Central Nervous System Hemangioblastomas.
    World Neurosurg. 2018 Sep;117:e187-e193

  10. Boku S, Izumi T, Abe S, Takahashi T, Nishi A, Nomaru H, Naka Y, Kang G, Nagashima M, Hishimoto A, Enomoto S, Duran-Torres G, Tanigaki K, Zhang J, Ye K, Kato S, Männistö PT, Kobayashi K, Hiroi N.Copy number elevation of 22q11.2 genes arrests the developmental maturation of working memory capacity and adult hippocampal neurogenesis.
    Mol Psychiatry. 2017 Aug 22. doi: 10.1038/mp.2017.158

  11. Nagura K, Takemoto Y, Moronaga S, Uchida Y, Shimono S, Shiino A, Tanigaki K, Amano T, Yoshino F, Noda Y, Koizumi S, Komatsu N, Kato T, Yamauchi J, Tamura R.Preparation of Robust Metal-Free Magnetic Nanoemulsions Encapsulating Low-Molecular-Weight Nitroxide Radicals and Hydrophobic Drugs Directed Toward MRI-Visible Targeted Delivery.
    Chemistry. 2017 Nov 7;23(62):15713-15720.

  12. Takada S, Hojo M, Tanigaki K, Miyamoto S. Contribution of Endothelial-to-Mesenchymal Transition to the Pathogenesis of Human Cerebral and Orbital Cavernous Malformations.
    Neurosurgery. 2017 Jul 1;81(1):176-183.

  13. Toritsuka M, Kimoto S, Muraki K, Kitagawa M, Kishimoto T, Sawa A, Tanigaki K. Regulation of striatal dopamine responsiveness by Notch/RBP-J signaling.
    Transl Psychiatry. 2017 Mar 7;7(3):e1049.

  14. A Shiino, YW Chen, K Tanigaki, A Yamada, P Vigers, T Watanabe, I Tooyama, I Akiguchi. Sex-related difference in human white matter volumes studied: Inspection of the corpus callosum and other white matter by VBM. Sci Rep. 2017 Jan 3;7:39818

  15. Y Yoshimura, A Shiino, K Muraki, T Fukami, S Yamada, T Satow,, M Fukuda, M Saiki, M Hojo, S Miyamoto, N Onishi, H Saya, T Inubushi, K Nozaki, K TanigakiArsenic trioxide sensitizes glioblastoma to a Myc inhibitorPloS one. 2015 10 (6), e0128288

  16. M Isobe, K Tanigaki#, K Muraki, J Miyata, A Takemura, G Sugihara , H Takahashi, T Aso, H Fukuyama, M Hazama, T Murai# (#: equal correspondence) Polymorphism within a Neuronal Activity-Dependent Enhancer of NgR1 Is Associated with Corpus Callosum Morphology in Humans
    Molecular Neuropsychiatry, 2015 1 (2), 105-115

  17. K Muraki, K TanigakiNeuronal migration abnormalities and its possible implications for schizophrenia
    Frontiers in neuroscience 2015, 9: 74

  18. Toritsuka M, Kimoto S, Muraki K, Landek-Salgado MA, Yoshida A, Yamamoto N, Horiuchi Y, Hiyama H, Tajinda K, Keni N, Illingworth E, Iwamoto T, Kishimoto T, Sawa A, Tanigaki K. Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model.
    Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17552-7

  19. Marumo T, Takagi Y, Muraki K, Hashimoto N, Miyamoto S, Tanigaki K. Notch signaling regulates nucleocytoplasmic Olig2 translocation in reactive astrocytes differentiation after ischemic stroke.
    Neurosci. Res. 2013 Mar;75(3):204-9.

  20. Kimoto S, Muraki K, Toritsuka M, Mugikura S, Kajiwara K, Kishimoto T, Illingworth E, Tanigaki K. Selective overexpression of Comt in prefrontal cortex rescues schizophrenia-like phenotypes in a mouse model of 22q11 deletion syndrome. Transl Psychiatry. 2012 Aug 7;2:e146

  21. Harper KM, Hiramoto T, Tanigaki K, Kang G, Suzuki G, Trimble W, Hiroi N. Alterations of social interaction through genetic and environmental manipulation of the 22q11.2 gene Sept5 in the mouse brain.
    Hum Mol Genet. 2012 Aug 1;21(15):3489-99.

  22. Yoshida A, Yamamoto N, Kinoshita M, Hiroi N, Hiramoto T, Kang G, Trimble WS, Tanigaki K, Nakagawa T, Ito J. Localization of septin proteins in the mouse cochlea.
    Hear Res. 2012 Jul;289(1-2):40-51.

  23. Ishifune C, Maekawa Y, Nishida J, Kitamura A, Tanigaki K, Yagita H, Yasutomo K. Notch signaling regulates the development of a novel type of Thy1-expressing dendritic cell in the thymus.
    Eur J Immunol. 2011 May;41(5):1309-20.

  24. Tanigaki K, Honjo T. Two opposing roles of RBP-J in Notch signaling.
    Curr Top Dev Biol. 2010;92:231-52.

  25. Alam MS, Maekawa Y, Kitamura A, Tanigaki K, Yoshimoto T, Kishihara K, Yasutomo K. Notch signaling drives IL-22 secretion in CD4+ T cells by stimulating the aryl hydrocarbon receptor.
    Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5943-8.

  26. Fujimoto M, Takagi Y, Muraki K, Nozaki K, Yamamoto N, Tsuji M, Hashimoto N, Honjo T, Tanigaki K. RBP-J promotes neuronal differentiation and inhibits oligodendroglial development in adult neurogenesis.
    Dev Biol. 2009 Aug 15;332(2):339-50.

  27. Suzuki G, Harper KM, Hiramoto T, Sawamura T, Lee M, Kang G, Tanigaki K, Buell M, Geyer MA, Trimble WS, Agatsuma S, Hiroi N. Sept5 deficiency exerts pleiotropic influence on affective behaviors and cognitive functions in mice.
    Hum Mol Genet. 2009 May 1;18(9):1652-60.

  28. Carlén M, Meletis K, Göritz C, Darsalia V, Evergren E, Tanigaki K, Amendola M, Barnabé-Heider F, Yeung MS, Naldini L, Honjo T, Kokaia Z, Shupliakov O, Cassidy RM, Lindvall O, Frisén J.Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke.
    Nat Neurosci. 2009 Mar;12(3):259-67.

  29. Komine O, Nagaoka M, Watase K, Gutmann DH, Tanigaki K, Honjo T, Radtke F, Saito T, Chiba S, Tanaka K.The monolayer formation of Bergmann glial cells is regulated by Notch/RBP-J signaling.
    Dev Biol. 2007 Nov 1;311(1):238-250. Epub 2007 Aug 31.

  30. Fujikura J, Hosoda K, Kawaguchi Y, Noguchi M, Iwakura H, Odori S, Mori E, Tomita T, Hirata M, Ebihara K, Masuzaki H, Fukuda A, Furuyama K, Tanigaki K, Yabe D, Nakao K. Rbp-j regulates expansion of pancreatic epithelial cells and their differentiation into exocrine cells during mouse development.
    Dev Dyn. 2007 Oct;236(10):2779-91.

  31. Tanigaki K, Honjo T Regulation of lymphocyte development by Notch signaling.
    Nat Immunol. 2007 May;8(5):451-6.

  32. Souilhol C, Cormier S, Tanigaki K, Babinet C, Cohen-Tannoudji M. RBP-Jkappa-dependent notch signaling is dispensable for mouse early embryonic development.
    Mol Cell Biol. 2006 Jul;26(13):4769-74.

33. Tanaka S, Tsukada J, Suzuki W, Hayashi K, Tanigaki K, Tsuji M, Inoue H, Honjo T, Kubo M.The interleukin-4 enhancer CNS-2 is regulated by Notch signals and controls initial expression in NKT cells and memory- type CD4 T cells.
Immunity. 2006 Jun;24(6):689-701.

34. Buono KD, Robinson GW, Martin C, Shi S, Stanley P, Tanigaki K, Honjo T, Hennighausen L. The canonical Notch/RBP-J signaling pathway controls the balance of cell lineages in mammary epithelium during pregnancy.
Dev Biol. 2006 May 15;293(2):565-80. Epub 2006 Apr 11.

35. Fujikura J, Hosoda K, Iwakura H, Tomita T, Noguchi M, Masuzaki H, Tanigaki K, Yabe D, Honjo T, Nakao K. Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas. Cell Metab. 2006 Jan;3(1):59-65.

36. Yamamoto N, Tanigaki K, Tsuji M, Yabe D, Ito J, and Honjo T. Inhibition of Notch/RBP-J signaling induces hair cell formation in neonate mouse cochleas.
J. Mol.Med. 2006 Jan;84(1):37-45. Epub 2005 Nov 8.

37. Krebs LT, Shutter JR, Tanigaki K, Honjo T, Stark KL, Gridley T. Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants.
Genes Dev. 18(20):2469-73、2004

38. Tanigaki K, Tsuji M, Yamamoto N, Han H, Kubo M, Inoue H,Honjo T. Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses
by Notch/RBP-J signaling.
Immunity. 20(5):611-22, 2004

39. Amsen D, Blander JM, Lee GR, Tanigaki K, Honjo T, Flavell RA. Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cell
Cell. 14;117(4):515-26, 2004

40. Qin H, Wang J, Liang Y, Taniguchi Y, Tanigaki K, Han H. RING1 inhibits transactivation of RBP-J by Notch through interaction with LIM protein KyoT2.

Nucleic Acids Res. 32(4):1492-501, 2004

41. Tanigaki K, Kuroda K, Han H, Honjo T. Regulation of B cell development by Notch/RBP-J signaling.
Semin Immunol. 15(2):113-9, 2003

42. Kuroda K, Han H, Tani S, Tanigaki K, Tun T, Furukawa T, Taniguchi Y, Kurooka H, Hamada Y, Toyokuni S, Honjo T. Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway. Immunity. 18(2):301-12, 2003

43. Yamamoto N, Tanigaki K, Han H, Hiai H, Honjo T. Notch/RBP-J signaling regulates epidermis/hair fate determination of hair follicular stem cells.
Curr Biol. 13(4):333-8, 2003

44. Han H, Tanigaki K, Yamamoto N, Kuroda K, Yoshimoto M, Nakahata T, Ikuta K, Honjo T. Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision.
Int Immunol. 14(6):637-45, 2002

45. Tanigaki K, Han H, Yamamoto N, Tashiro K, Ikegawa M, Kuroda K, Suzuki A, Nakano T, Honjo T.Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells.
Nat Immunol. 3(5):443-50, 2002

46. Kobuke K, Furukawa Y, Sugai M, Tanigaki K, Ohashi N, Matsumori A, Sasayama S, Honjo T, Tashiro K. ESDN, a novel neuropilin-like membrane protein cloned from vascular cells with the longest secretory signal sequence among eukaryotes, is up-regulated after vascular injury.
J Biol Chem. 276(36):34105-14, 2001

47. Tanigaki K, Nogaki F, Takahashi J, Tashiro K, Kurooka H, Honjo T. Notch1 and Notch3 instructively restrict bFGF-responsive multipotent
neural progenitor cells to an astroglial fate.
Neuron. 29(1):45-55, 2001

和文著書

  1. 谷垣 健二、遺伝背景と喫煙、最新精神医学 16号4号, 2011, in press
  2. 谷垣 健二、大脳皮質層構造発生の分子生物学、脳神経外科速報,vol17, no3,340-346,2007
  3. 谷垣 健二、精神疾患の分子遺伝学、こころの臨床アラカルトvol26, no2, 231-236, 2007
  4. 谷垣 健二、動物モデルを通してみた統合失調、月刊精神科、vol8, no3, 176-180, 2006

十名理沙(とな りさ)

  1. Babahosseini H, Belyantseva IA, Yousaf R, Tona R, Hadi S, Inagaki S, Wilson E, Kitajiri SI, Frolenkov GI, Friedman TB, Cartagena-Rivera AX. Unbalanced bidirectional radial stiffness gradients within the organ of Corti promoted by TRIOBP. Proc Natl Acad Sci U S A. 2022 Jun 28;119(26):e2115190119.
  2.  Adeyemo A, Faridi R, Chattaraj P, Yousaf R, Tona R, Okorie S, Bharadwaj T, Nouel-Saied LM, Acharya A, Schrauwen I, Morell RJ, Leal SM, Friedman TB, Griffith AJ, Roux I. Genomic analysis of childhood hearing loss in the Yoruba population of Nigeria. Eur J Hum Genet. 2022 Jan;30(1):42-52.
  3. Iwasa YI, Nishio SY, Yoshimura H, Sugaya A, Kataoka Y, Maeda Y, Kanda Y, Nagai K, Naito Y, Yamazaki H, Ikezono T, Matsuda H, Nakai M, Tona R, Sakurai Y, Motegi R, Takeda H, Kobayashi M, Kihara C, Ishino T, Morita SY, Iwasaki S, Takahashi M, Furutate S, Oka SI, Kubota T, Arai Y, Kobayashi Y, Kikuchi D, Shintani T, Ogasawara N, Honkura Y, Izumi S, Hyogo M, Ninoyu Y, Suematsu M, Nakayama J, Tsuchihashi N, Okami M, Sakata H, Yoshihashi H, Kobayashi T, Kumakawa K, Yoshida T, Esaki T, Usami SI. Detailed clinical features and genotype-phenotype correlation in an OTOF-related hearing loss cohort in Japan. Hum Genet. 2022 Apr;141(3-4):865-875.
  4. Ramzan M, Philippe C, Belyantseva IA, Nakano Y, Fenollar-Ferrer C, Tona R, Yousaf R, Basheer R, Imtiaz A, Faridi R, Munir Z, Idrees H, Salman M, Nambot S, Vitobello A, Kartti S, Zarrik O, Witmer PD, Sobreria N, Ibrahimi A, Banfi B, Moutton S, Friedman TB, Naz S. Variants of human CLDN9 cause mild to profound hearing loss. Hum Mutat. 2021 Oct;42(10):1321-1335.
  5. Tona R, Lopez IA, Fenollar-Ferrer C, Faridi R, Anselmi C, Khan AA, Shahzad M, Morell RJ, Gu S, Hoa M, Dong L, Ishiyama A, Belyantseva IA, Riazuddin S, Friedman TB. Mouse Models of Human Pathogenic Variants of TBC1D24 Associated with Non-Syndromic Deafness DFNB86 and DFNA65 and Syndromes Involving Deafness. Genes (Basel). 2020 Sep 24;11(10):1122.
  6. Morell RJ, Olszewski R, Tona R, Leitess S, Wafa TT, Taukulis I, Schultz JM, Thomason EJ, Richards K, Whitley BN, Hill C, Saunders T, Starost MF, Fitzgerald T, Wilson E, Ohyama T, Friedman TB, Hoa M. Noncoding Microdeletion in Mouse Hgf Disrupts Neural Crest Migration into the Stria Vascularis, Reduces the Endocochlear Potential, and Suggests the Neuropathology for Human Nonsyndromic Deafness DFNB39. J Neurosci. 2020 Apr 8;40(15):2976-2992.
  7.  Katsuno T, Belyantseva IA, Cartagena-Rivera AX, Ohta K, Crump SM, Petralia RS, Ono K, Tona R, Imtiaz A, Rehman A, Kiyonari H, Kaneko M, Wang YX, Abe T, Ikeya M, Fenollar-Ferrer C, Riordan GP, Wilson EA, Fitzgerald TS, Segawa K, Omori K, Ito J, Frolenkov GI, Friedman TB, Kitajiri SI. TRIOBP-5 sculpts stereocilia rootlets and stiffens supporting cells enabling hearing. JCI Insight. 2019 Jun 20;4(12):e128561.
  8. Tona R, Chen W, Nakano Y, Reyes LD, Petralia RS, Wang YX, Starost MF, Wafa TT, Morell RJ, Cravedi KD, du Hoffmann J, Miyoshi T, Munasinghe JP, Fitzgerald TS, Chudasama Y, Omori K, Pierpaoli C, Banfi B, Dong L, Belyantseva IA, Friedman TB. The phenotypic landscape of a Tbc1d24 mutant mouse includes convulsive seizures resembling human early infantile epileptic encephalopathy. Hum Mol Genet. 2019 May 1;28(9):1530-1547
  9. Faridi R, Tona R, Brofferio A, Hoa M, Olszewski R, Schrauwen I, Assir MZK, Bandesha AA, Khan AA, Rehman AU, Brewer C, Ahmed W, Leal SM, Riazuddin S, Boyden SE, Friedman TB. Mutational and phenotypic spectra of KCNE1 deficiency in Jervell and Lange-Nielsen Syndrome and Romano-Ward Syndrome. Hum Mutat. 2019 Feb;40(2):162-176.
  10. Yamamoto R, Naito Y, Tona R, Moroto S, Tamaya R, et al. Audio-visual speech perception in prelingually deafened Japanese children following sequential bilateral cochlear implantation. Int J Pediatr Otorhinolaryngol. 2017 :160-168.
  11. Tona R, Naito Y, Moroto S, Yamamoto R, Fujiwara K, Yamazaki H, et al. Audio-visual integration during speech perception in prelingually deafened Japanese children revealed by the McGurk effect. Int J Pediatr Otorhinolaryngol. 2015 ;79(12):2072-8.

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