当研究所画像研究部門におけるタウ蛋白トレーサ18F-Florzolotau PETを用いた研究につき山内浩前副所長が執筆した論文が、国際誌『Stroke』に掲載されました。

掲載日
2022年11月7日
雑誌名
Stroke 2022 Dec；53(12):e500-e503. doi: 10.1161/STROKEAHA.122.040493. Epub 2022 Nov 7.
著者
Yamauchi H, Kagawa S, Kusano K, Ito M, Okuyama C
題名
Misery Perfusion and Tau Deposition in Atherosclerotic Major Cerebral Artery Disease: A 18F-Florzolotau Positron Emission Tomography Study
要旨
Abstract：Background: Studies using animal models have shown that cerebral hypoperfusion causes hyperphosphorylation of tau protein, leading to neuronal damage. However, the relationship between hypoperfusion and tau deposition in humans is unclear. Hence, we aimed to determine whether
cerebral hypoperfusion leading to decreased blood flow relative to metabolic demand [increased oxygen extraction fraction (OEF), misery perfusion] is associated with increased tau deposition in patients with atherosclerotic internal carotid artery or middle cerebral artery disease.
Methods：We prospectively evaluated the distribution of tau aggregate deposition using positron emission tomography and 18F-florzolotau (PMPBB3 [1-fluoro-3-((2-((1E,3E)-4-(6-(methylamino)pyridine-3-yl)buta-1,3-dien-1-yl)benzo[d]thiazol-6-yl)oxy)propan-2-ol)]) in 8 patients with
atherosclerotic disease of the internal carotid artery or middle cerebral artery. The standardized uptake value ratio of 18F-florzolotau at 100 to 110 minutes after injection was calculated using the cerebellar cortex as a
reference region and was correlated with OEF obtained from 15O-gas positron emission tomography in the middle cerebral artery distributions. Results: Significant decreases in cerebral blood flow and cerebral metabolic rate of oxygen and increases in OEF were found in the hemisphere
ipsilateral to the arterial lesion. 18F-florzolotau standardized uptake value ratio in this region was also greater than that in the contralateral hemisphere. In the ipsilateral hemisphere, 18F-florzolotau standardized uptake value ratio positively correlated with OEF values.
Conclusions: This pilot study with a small sample size suggests that increases in OEF-misery perfusion-may be associated with increased tau aggregates deposition in atherosclerotic internal carotid artery or middle cerebral artery disease.
日本語要旨
脳の低血流がリン酸化タウ蛋白の蓄積の原因となり脳損傷を引き起こすことが動物実験で示されているが、ヒトにおける脳血流とタウ蛋白蓄積の関連性についてはよくわかっていない。我々は、貧困還流を反映する酸素摂取率（OEF）の上昇とタウ蓄積との関係を、18F-Florzolotau（18F-PM-PBB3）PETを用いて検討した。8例の動脈硬化性の内頚動脈あるいは中大脳動脈狭窄を有する患者において15O-gas PETによる中大脳動脈領域におけるOEFと、18F-Florzolotauの大脳皮質の集積値
（小脳皮質の集積値に対する比SUVR）を計測したところ、狭窄側において、酸素代謝量と脳血流の減少、OEFの増加がみられ、18F-Florzolotauの集積は同側で高く、OEFと正の相関を示した。貧困還流がタウ蛋白蓄積と関連する可能性が示唆された。