更新日：2023年1月3日

谷垣専門研究員が第45回日本分子生物学会で発表しました

• 日付
  2022年12月31日
• 発表日
  2022年11月30日
• 学会名
  第45回日本分子生物学会
• 開催地
  幕張メッセ
• 演題
  Neuropathological analysis of Notch4 knockout mice.
• 演者
  Kenji Tanigaki
• 要旨
  Notch4 has been reported to be associated with schizophrenia. Rats with reduced g-secretase activity show behavioral abnormalities such as increased sensitivity to apomorphine.
  Conditional deletion of RBP-J specifically in neuronal cells drastically reduced dopamine release in the striatum and caused a subtle decrease in the number of dopaminergic neurons.
  RBP-J signaling regulates dopamine responsiveness in the striatum, which night suggest the possible involvement of Notch/RBP-J signaling in schizophrenia. However, it remains to be elucidated how Notch4 interacts with RBP-J and increases the risk of schizophrenia.
  To elucidate the functions of Notch4 in the pathogenesis of schizophrenia, we performed behavioral analysis of Notch4-deficient mice and examined their responses to dopaminergic stimulation. We would like to discuss the possible roles of Notch4 in the pathogenesis of schizophrenia.