更新日：2024年7月7日

奥山上席専門研究員が執筆したアミロイドPETの新しい解析法に関する論文が英文誌に掲載されました

• 日付
  2024年6月22日
• 発行日
  2024年6月22日 Epub ahead of print
• 雑誌名
  Ann Nucl Med doi: 10.1007/s12149-024-01956-y.
• 題名
  New objective simple evaluation methods of amyloid PET/CT using whole-brain histogram and Top20%-Map
• 執筆者
  Okuyama C, Higashi T, Ishizu K, Oishi N, Kusano K, Ito M, Kagawa S,Okina T, Suzuki N, Hasegawa H, Nagahama Y, Watanabe H, Ono M, Yamauchi H.
• 要旨
  Objective: This study aims to assess the utility of newly developed objective methods for the evaluation of intracranial abnormal amyloid deposition using PET/CT histogram without use of cortical ROI analyses.
  Methods: Twenty-five healthy volunteers (HV) and 38 patients with diagnosed or suspected dementia who had undergone 18F-FPYBF-2 PET/CT were retrospectively included in this study. Out of them, 11C-PiB PET/CT had been also performed in 13 subjects. In addition to the
  conventional methods, namely visual judgment and quantitative analyses using composed standardized uptake value ratio (comSUVR), the PET images were also evaluated by the following new parameters: the skewness and the mode-to-mean ratio (MMR) obtained
  rom the histogram of the brain parenchyma； Top20%-map highlights the areas with high tracer accumulation occupying 20% volume of the total brain parenchymal on the individual’s CT images.
  We evaluated the utility of the new methods using histogram compared with the visual assessment and comSUVR. The results of these new methods between 18F-FPYBF-2 and 11C-PiB were also compared in 13 subjects.