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神経病態研究部門の谷垣専門研究員らが第44回日本分子生物学会で発表しました。

日付2021年12月5日
発表日2021年12月2日
学会名第44回日本分子生物学会
開催地パシフィコ横浜
演題Notch4ノックアウトマウスの行動学的解析
演者谷垣健二
要旨Notch4 has been reported to be associated with schizophrenia. Rats with reduced g-secretase activity show behavioral abnormalities such as increased sensitivity to apomorphine. These findings suggest the possible involvement of Notch/RBP-J signaling in schizophrenia.
Notch/RBP-J signaling regulates multiple developmental processes in embryonic stages.However, its physiological roles in the brain remain unknown.
To elucidate the functions of Notch signaling in the central nervous system, we performed behavioral analysis of Notch4-deficient mice and examined their responses to dopaminergic stimulation. We would like to discuss the possible roles of Notch4 in the pathogenesis of schizophrenia.